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For this reason, some coalescence events between NGO and SAN could correspond to the specialist-generalist split or other historic occasions, along with the invasion dynamics we are thinking about. Nevertheless, NGO supplies one of the best out there proxy for human-specialist populations in their native habitat, and the noticed migration signal should largely mirror the time course of their unfold to the Americas. One way to date the evolution of specialization on people in Ae. Aegypti is to look at the time course of divergence between specialist and generalist populations using cross-coalescent analysis. Coalescent approaches mannequin relationships between haplotypes at a locus going backward in time, using the steady accumulation of mutations to estimate when haplotypes merge right into a single ancestral sequence (Schiffels and Wang, 2020). Using the Multiple Sequentially Markovian Coalescent (MSMC), one can characterize the distribution of times to coalescence throughout genome-wide loci (Schiffels and Wang, 2020).

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